|
Date |
Name |
Title |
Volume |
Trade Price |
Holding Change |
|
5/22/2013
|
ADAGE CAPITAL PARTNERS GP LLC
|
Substantial Shareholder
|
-50,000
|
$24.00
|
-1.21%
|
|
5/14/2013
|
HEIDEN WILLIAM K
|
President and CEO
|
-8,162
|
$25.03
|
-10.61%
|
|
2/26/2013
|
White Christopher G
|
Chief Business Officer
|
-400
|
$16.37
|
-100.00%
|
|
2/25/2013
|
White Christopher G
|
Chief Business Officer
|
-433
|
$16.39
|
-51.98%
|
|
1/9/2013
|
White Christopher G
|
Chief Business Officer
|
-3,000
|
$15.80
|
-100.00%
|
|
1/8/2013
|
White Christopher G
|
Chief Business Officer
|
-3,000
|
$15.87
|
-50.00%
|
|
1/7/2013
|
White Christopher G
|
Chief Business Officer
|
-4,000
|
$16.07
|
-66.67%
|
|
1/4/2013
|
White Christopher G
|
Chief Business Officer
|
-4,000
|
$16.03
|
-40.00%
|
|
1/3/2013
|
THOMAS FRANK E
|
EVP, COO
|
-10,000
|
$15.60
|
-31.25%
|
|
12/5/2012
|
Holmes Scott A
|
Chief Accounting Officer
|
-2,500
|
$14.79
|
-100.00%
|
|
11/30/2012
|
THOMAS FRANK E
|
EVP, COO
|
-5,000
|
$15.08
|
-29.41%
|
|
9/12/2012
|
Holmes Scott A
|
Chief Accounting Officer
|
-750
|
$15.54
|
-100.00%
|
|
8/6/2012
|
White Christopher G
|
Chief Business Officer, SVP
|
-3,750
|
$14.29
|
-100.00%
|
|
4/2/2012
|
THOMAS FRANK E
|
COO, Interim President and CEO
|
500
|
$15.86
|
33.33%
|
|
3/2/2012
|
ADAGE CAPITAL PARTNERS GP LLC
|
TenPercent
|
47,034
|
$15.97
|
1.15%
|
|
3/1/2012
|
ADAGE CAPITAL PARTNERS GP LLC
|
TenPercent
|
364,387
|
$15.55
|
9.79%
|
|
3/1/2012
|
THOMAS FRANK E
|
COO, Interim CEO and President
|
500
|
$15.81
|
50.00%
|
|
2/24/2012
|
Farmer Joseph L
|
General Counsel, SVP
|
-833
|
$15.82
|
-100.00%
|
|
2/24/2012
|
White Christopher G
|
Chief Business Officer and SVP
|
-833
|
$15.82
|
-100.00%
|
|
2/1/2012
|
THOMAS FRANK E
|
COO, Interim CEO and President
|
500
|
$16.56
|
100.00%
|
|
1/9/2012
|
Farmer Joseph L
|
SVP, General Counsel
|
-8,000
|
$19.09
|
-100.00%
|
|
1/9/2012
|
White Christopher G
|
Chief Business Officer and SVP
|
-8,000
|
$17.09
|
-100.00%
|
|
1/9/2012
|
Farmer Joseph L
|
SVP, General Counsel
|
-8,000
|
$17.09
|
-100.00%
|
|
12/14/2011
|
ALLEN LEE F MD PhD
|
Chief Medical Officer and EVP
|
5,577
|
$18.38
|
166.58%
|
|
11/30/2011
|
ALLEN LEE F MD PhD
|
Chief Medical Officer and EVP
|
242
|
$15.13
|
3.20%
|
|
8/11/2011
|
ALLEN LEE F MD PhD
|
Chief Medical Officer and EVP
|
-1,959
|
$15.04
|
-20.57%
|
|
8/5/2011
|
Farmer Joseph L
|
SVP, General Counsel
|
-2,500
|
$15.71
|
-100.00%
|
|
5/31/2011
|
Arkowitz David
|
EVP, CFO, CBO
|
1,500
|
$13.23
|
490.20%
|
|
5/31/2011
|
ALLEN LEE F MD PhD
|
Chief Medical Officer and EVP
|
1,322
|
$13.23
|
67.76%
|
|
2/24/2011
|
Farmer Joseph L
|
SVP, General Counsel
|
-833
|
$17.10
|
-100.00%
|
|
2/24/2011
|
Arkowitz David
|
EVP, Chief Financial Officer
|
-500
|
$17.10
|
-16.61%
|
|
2/24/2011
|
Arkowitz David
|
EVP, Chief Financial Officer
|
-2,205
|
$17.06
|
-87.81%
|