|
Date |
Name |
Title |
Volume |
Trade Price |
Holding Change |
|
1/30/2013
|
ORBIMED ADVISORS LLC
|
Director
|
5,700,000
|
$0.66
|
323.50%
|
|
1/3/2013
|
Hislop Colin
|
Chief Medical Officer
|
-4,560
|
$0.69
|
-5.09%
|
|
1/3/2013
|
TRUEX PAUL F
|
President and CEO
|
-17,454
|
$0.69
|
-20.81%
|
|
1/3/2013
|
KILFOIL GEORGINA
|
SVP,Product Dev.& Project Mgmt
|
-2,410
|
$0.69
|
-7.43%
|
|
1/3/2013
|
LOWE CHRISTOPHER P.
|
C.F.O. and C.B.O.
|
-8,660
|
$0.69
|
-17.32%
|
|
1/3/2013
|
ODINK DEBRA
|
Chief Technology Officer
|
-3,409
|
$0.69
|
-9.68%
|
|
6/30/2012
|
KILFOIL GEORGINA
|
SVP,Product Dev.& Project Mgmt
|
-2,068
|
$0.69
|
-7.75%
|
|
6/30/2012
|
ODINK DEBRA
|
Chief Technology Officer
|
-1,838
|
$0.69
|
-6.89%
|
|
6/29/2012
|
TRUEX PAUL F
|
President and CEO
|
20,000
|
$0.76
|
3.20%
|
|
3/22/2012
|
ORBIMED ADVISORS LLC
|
Director
|
-1,306,700
|
$2.40
|
-50.45%
|
|
3/21/2012
|
ORBIMED ADVISORS LLC
|
Director
|
-125,000
|
$2.87
|
-4.60%
|
|
3/20/2012
|
ORBIMED ADVISORS LLC
|
Director
|
-116,800
|
$2.90
|
-4.12%
|
|
3/1/2012
|
ODINK DEBRA
|
Chief Technology Officer
|
-2,000
|
$6.57
|
-6.98%
|
|
2/23/2012
|
Hislop Colin
|
Chief Medical Officer
|
40,000
|
$0.26
|
101.22%
|
|
2/15/2012
|
TRUEX PAUL F
|
President and C.E.O.
|
-15,000
|
$7.84
|
-2.34%
|
|
2/3/2012
|
Hislop Colin
|
Chief Medical Officer
|
-30,000
|
$8.20
|
-51.75%
|
|
2/1/2012
|
LOWE CHRISTOPHER P.
|
C.F.O. and C.B.O.
|
-15,000
|
$7.66
|
-32.50%
|
|
2/1/2012
|
ODINK DEBRA
|
Chief Technology Officer
|
-2,000
|
$7.67
|
-8.61%
|
|
1/31/2012
|
TRUEX PAUL F
|
President and C.E.O.
|
20,000
|
$0.26
|
3.23%
|
|
1/28/2012
|
HEALY JAMES
|
Director
|
-12,000
|
$4.19
|
-27.00%
|
|
1/17/2012
|
TRUEX PAUL F
|
President and Chief Executive
|
-15,000
|
$6.75
|
-2.34%
|
|
1/10/2012
|
ODINK DEBRA
|
Chief Technology Officer
|
-800
|
$6.51
|
-3.33%
|
|
1/6/2012
|
ODINK DEBRA
|
Chief Technology Officer
|
-1,200
|
$6.50
|
-4.68%
|
|
12/30/2011
|
SOFINNOVA VENTURE PARTNERS VI L P
|
TenPercent
|
-20,630
|
$6.23
|
-0.62%
|
|
12/30/2011
|
SOFINNOVA VENTURE PARTNERS VI L P
|
TenPercent
|
-280
|
$6.23
|
-0.62%
|
|
12/30/2011
|
SOFINNOVA VENTURE PARTNERS VI L P
|
TenPercent
|
-4,090
|
$6.23
|
-0.62%
|
|
12/30/2011
|
HEALY JAMES
|
Senior Executive Officer
|
-280
|
$6.23
|
-0.62%
|
|
12/30/2011
|
HEALY JAMES
|
Senior Executive Officer
|
-4,090
|
$6.23
|
-0.62%
|
|
12/30/2011
|
HEALY JAMES
|
Senior Executive Officer
|
-20,630
|
$6.23
|
-0.62%
|
|
12/22/2011
|
HEALY JAMES
|
Senior Executive Officer
|
-20,630
|
$6.22
|
-0.62%
|
|
12/22/2011
|
HEALY JAMES
|
Senior Executive Officer
|
-4,090
|
$6.22
|
-0.62%
|
|
12/22/2011
|
HEALY JAMES
|
Senior Executive Officer
|
-280
|
$6.22
|
-0.61%
|
|
12/22/2011
|
SOFINNOVA VENTURE PARTNERS VI L P
|
TenPercent
|
-20,630
|
$6.22
|
-0.62%
|
|
12/22/2011
|
SOFINNOVA VENTURE PARTNERS VI L P
|
TenPercent
|
-280
|
$6.22
|
-0.61%
|
|
12/22/2011
|
SOFINNOVA VENTURE PARTNERS VI L P
|
TenPercent
|
-4,090
|
$6.22
|
-0.62%
|
|
12/21/2011
|
SOFINNOVA VENTURE PARTNERS VI L P
|
TenPercent
|
-280
|
$6.51
|
-0.61%
|
|
12/21/2011
|
SOFINNOVA VENTURE PARTNERS VI L P
|
TenPercent
|
-4,090
|
$6.51
|
-0.61%
|
|
12/21/2011
|
SOFINNOVA VENTURE PARTNERS VI L P
|
TenPercent
|
-20,630
|
$6.51
|
-0.61%
|
|
12/21/2011
|
HEALY JAMES
|
Senior Executive Officer
|
-280
|
$6.51
|
-0.61%
|
|
12/21/2011
|
HEALY JAMES
|
Senior Executive Officer
|
-20,630
|
$6.51
|
-0.61%
|
|
12/21/2011
|
HEALY JAMES
|
Senior Executive Officer
|
-4,090
|
$6.51
|
-0.61%
|
|
12/15/2011
|
TRUEX PAUL F
|
President and CEO
|
-15,000
|
$6.34
|
-2.28%
|
|
12/13/2011
|
ORBIMED ADVISORS LLC
|
Director
|
-16,200
|
$6.50
|
-0.57%
|
|
12/9/2011
|
ORBIMED ADVISORS LLC
|
Director
|
-40,000
|
$6.75
|
-1.39%
|
|
11/18/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-3,000
|
$6.50
|
-0.10%
|
|
11/17/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-24,000
|
$6.67
|
-0.82%
|
|
11/16/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-25,000
|
$6.87
|
-0.85%
|
|
11/15/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-50,000
|
$6.93
|
-1.67%
|
|
11/15/2011
|
TRUEX PAUL F
|
President and CEO
|
-15,000
|
$6.96
|
-2.23%
|
|
11/14/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-5,000
|
$6.95
|
-0.17%
|
|
11/11/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-5,000
|
$7.14
|
-0.17%
|
|
11/8/2011
|
Hislop Colin
|
Chief Medical Officer
|
15,000
|
$0.26
|
25.88%
|
|
11/8/2011
|
Hislop Colin
|
Chief Medical Officer
|
-15,000
|
$6.74
|
-20.56%
|
|
11/3/2011
|
LOWE CHRISTOPHER P.
|
Chief Financial Officer & CBO
|
-15,000
|
$6.88
|
-24.53%
|
|
10/25/2011
|
LOWE CHRISTOPHER P.
|
Chief Financial Officer & CBO
|
-4,637
|
$7.07
|
-100.00%
|
|
10/21/2011
|
TRUEX PAUL F
|
President and CEO
|
-11,356
|
$6.25
|
-1.72%
|
|
10/21/2011
|
TRUEX PAUL F
|
President and CEO
|
-11,879
|
$6.25
|
-1.83%
|
|
10/18/2011
|
TRUEX PAUL F
|
President and CEO
|
-6,745
|
$6.25
|
-1.01%
|
|
8/8/2011
|
TRUEX PAUL F
|
President and CEO
|
50,000
|
$0.26
|
123.42%
|
|
8/8/2011
|
LOWE CHRISTOPHER P.
|
Chief Financial Officer & CBO
|
10,000
|
$1.34
|
19.55%
|
|
8/3/2011
|
LOWE CHRISTOPHER P.
|
Chief Financial Officer & CBO
|
-14,600
|
$6.88
|
-22.20%
|
|
8/2/2011
|
LOWE CHRISTOPHER P.
|
Chief Financial Officer & CBO
|
-300
|
$7.93
|
-6.08%
|
|
8/2/2011
|
LOWE CHRISTOPHER P.
|
Chief Financial Officer & CBO
|
-4,700
|
$7.28
|
-48.77%
|
|
7/15/2011
|
TRUEX PAUL F
|
President and CEO
|
-15,000
|
$7.95
|
-2.20%
|
|
7/12/2011
|
Hislop Colin
|
Chief Medical Officer
|
15,000
|
$0.26
|
34.91%
|
|
7/7/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
7,200
|
$4.19
|
0.13%
|
|
7/7/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
3,115
|
$1.51
|
0.06%
|
|
7/7/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
9,248
|
$1.34
|
0.17%
|
|
6/30/2011
|
TRUEX PAUL F
|
President and CEO
|
-48,500
|
$8.17
|
-54.49%
|
|
6/30/2011
|
LOWE CHRISTOPHER P.
|
Chief Financial Officer & CBO
|
-23,500
|
$8.17
|
-26.33%
|
|
6/30/2011
|
KILFOIL GEORGINA
|
SVP, Prod. Dev. & Project Mngm
|
-5,625
|
$8.17
|
-25.00%
|
|
6/30/2011
|
Hislop Colin
|
Chief Medical Officer
|
-17,500
|
$8.17
|
-28.94%
|
|
6/30/2011
|
ODINK DEBRA
|
VP, Pharmaceutical R&D
|
-3,670
|
$8.17
|
-12.52%
|
|
6/29/2011
|
Hislop Colin
|
Chief Medical Officer
|
10,000
|
$0.26
|
19.98%
|
|
6/21/2011
|
LOWE CHRISTOPHER P.
|
Chief Financial Officer & CBO
|
2,920
|
$0.14
|
4.32%
|
|
6/21/2011
|
LOWE CHRISTOPHER P.
|
Chief Financial Officer & CBO
|
17,080
|
$1.51
|
24.20%
|
|
6/16/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-2,809
|
$8.67
|
-0.06%
|
|
6/16/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-281
|
$8.67
|
-0.06%
|
|
6/16/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-10
|
$8.67
|
-0.06%
|
|
6/15/2011
|
TRUEX PAUL F
|
President and CEO
|
-15,000
|
$8.30
|
-2.15%
|
|
6/14/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-2
|
$8.81
|
-0.01%
|
|
6/14/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-63
|
$8.81
|
-0.01%
|
|
6/14/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-634
|
$8.81
|
-0.01%
|
|
6/13/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-1,178
|
$8.80
|
-0.02%
|
|
6/13/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-118
|
$8.80
|
-0.02%
|
|
6/13/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-4
|
$8.80
|
-0.02%
|
|
6/10/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-30,000
|
$8.18
|
-0.99%
|
|
6/9/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-37,000
|
$8.11
|
-1.21%
|
|
6/8/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-33,000
|
$8.02
|
-1.06%
|
|
5/26/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-16
|
$8.60
|
-0.09%
|
|
5/26/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-435
|
$8.60
|
-0.09%
|
|
5/26/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-4,349
|
$8.60
|
-0.09%
|
|
5/26/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-34,200
|
$8.53
|
-100.00%
|
|
5/25/2011
|
ORBIMED ADVISORS LLC
|
Senior Executive Officer
|
-4,800
|
$8.65
|
-100.00%
|
|
5/25/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-108
|
$8.67
|
-0.61%
|
|
5/25/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-2,970
|
$8.67
|
-0.61%
|
|
5/25/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-29,672
|
$8.67
|
-0.61%
|
|
5/24/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-172
|
$8.42
|
-0.96%
|
|
5/24/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-4,734
|
$8.42
|
-0.96%
|
|
5/24/2011
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
|
TenPercent
|
-47,290
|
$8.42
|
-0.96%
|