|
Date |
Name |
Title |
Volume |
Trade Price |
Holding Change |
|
2/28/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
51,248
|
$29.11
|
0.66%
|
|
2/28/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,353
|
$29.11
|
0.63%
|
|
2/27/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
974
|
$29.03
|
0.46%
|
|
2/27/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
36,881
|
$29.03
|
0.48%
|
|
2/27/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
4,270
|
$29.03
|
0.30%
|
|
2/24/2012
|
Popovits Kimberly J
|
President and CEO
|
-5,000
|
$28.85
|
-1.88%
|
|
2/23/2012
|
Shak Steven
|
Chief Medical Officer
|
-5,000
|
$28.15
|
-1.29%
|
|
2/23/2012
|
Popovits Kimberly J
|
President and CEO
|
-5,000
|
$28.15
|
-1.85%
|
|
2/23/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
7,477
|
$28.12
|
0.53%
|
|
2/23/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,639
|
$28.12
|
0.77%
|
|
2/23/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
62,098
|
$28.12
|
0.81%
|
|
2/22/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
5,511
|
$27.98
|
0.07%
|
|
2/22/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
145
|
$27.98
|
0.07%
|
|
2/22/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
638
|
$27.98
|
0.05%
|
|
2/21/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
5,217
|
$27.98
|
0.37%
|
|
2/21/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,238
|
$27.98
|
0.59%
|
|
2/21/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
46,909
|
$27.98
|
0.62%
|
|
2/16/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
91,543
|
$29.86
|
1.22%
|
|
2/16/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
93,088
|
$29.61
|
1.26%
|
|
2/16/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
2,419
|
$29.86
|
1.16%
|
|
2/16/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
2,460
|
$29.61
|
1.20%
|
|
2/16/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
10,838
|
$29.86
|
0.78%
|
|
2/16/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
11,021
|
$29.61
|
0.80%
|
|
2/15/2012
|
Schorno Dean L
|
CFO
|
-545
|
$28.97
|
-2.61%
|
|
2/15/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
3,944
|
$28.88
|
0.29%
|
|
2/15/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
849
|
$28.88
|
0.41%
|
|
2/15/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
32,125
|
$28.88
|
0.44%
|
|
2/15/2012
|
Shak Steven
|
Chief Medical Officer
|
-629
|
$28.97
|
-0.16%
|
|
2/15/2012
|
Scott Randal W
|
Executive Chairman
|
-629
|
$28.97
|
-0.05%
|
|
2/15/2012
|
Schorno Dean L
|
CFO
|
-755
|
$28.76
|
-3.45%
|
|
2/15/2012
|
Schorno Dean L
|
CFO
|
-545
|
$28.97
|
-2.58%
|
|
2/15/2012
|
Popovits Kimberly J
|
President and CEO
|
-1,396
|
$28.97
|
-6.98%
|
|
2/15/2012
|
Cole G Bradley
|
COO
|
-943
|
$28.97
|
-6.53%
|
|
2/15/2012
|
Baker Joffre
|
Chief Scientific Officer
|
-629
|
$28.97
|
-0.47%
|
|
2/15/2012
|
Schorno Dean L
|
CFO
|
-1,000
|
$28.76
|
-4.57%
|
|
2/14/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
7,341
|
$28.44
|
0.53%
|
|
2/14/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,475
|
$28.44
|
0.73%
|
|
2/14/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
55,804
|
$28.44
|
0.76%
|
|
2/10/2012
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$26.25
|
-0.75%
|
|
2/10/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
112,735
|
$26.60
|
1.57%
|
|
2/10/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
18,628
|
$26.62
|
0.26%
|
|
2/10/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
28,469
|
$26.52
|
0.39%
|
|
2/10/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
2,980
|
$26.60
|
1.50%
|
|
2/10/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
492
|
$26.62
|
0.24%
|
|
2/10/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
753
|
$26.52
|
0.37%
|
|
2/10/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
17,339
|
$26.60
|
1.29%
|
|
2/10/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
2,865
|
$26.62
|
0.21%
|
|
2/10/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
4,378
|
$26.52
|
0.32%
|
|
2/10/2012
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$26.25
|
-0.75%
|
|
2/9/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
3,883
|
$26.24
|
0.05%
|
|
2/9/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
49,670
|
$26.33
|
0.70%
|
|
2/9/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
2,441
|
$26.27
|
0.03%
|
|
2/9/2012
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$26.10
|
-0.74%
|
|
2/9/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
64
|
$26.27
|
0.03%
|
|
2/9/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,312
|
$26.33
|
0.66%
|
|
2/9/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
102
|
$26.24
|
0.05%
|
|
2/9/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
387
|
$26.27
|
0.03%
|
|
2/9/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
7,858
|
$26.33
|
0.59%
|
|
2/9/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
615
|
$26.24
|
0.05%
|
|
2/9/2012
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$26.10
|
-0.74%
|
|
2/8/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
135,681
|
$26.18
|
1.96%
|
|
2/8/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
6,093
|
$26.17
|
0.09%
|
|
2/8/2012
|
Cole G Bradley
|
COO
|
-2,500
|
$26.47
|
-14.75%
|
|
2/8/2012
|
Cole G Bradley
|
COO
|
2,500
|
$1.33
|
17.30%
|
|
2/8/2012
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
60,315
|
$26.26
|
0.86%
|
|
2/8/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
161
|
$26.17
|
0.08%
|
|
2/8/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
3,585
|
$26.18
|
1.87%
|
|
2/8/2012
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,594
|
$26.26
|
0.81%
|
|
2/8/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
999
|
$26.17
|
0.08%
|
|
2/8/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
22,251
|
$26.18
|
1.70%
|
|
2/8/2012
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
9,891
|
$26.26
|
0.74%
|
|
1/26/2012
|
LIVINGSTON RANDALL S
|
Director
|
-2,000
|
$27.51
|
-24.54%
|
|
1/26/2012
|
LIVINGSTON RANDALL S
|
Director
|
2,000
|
$1.33
|
32.53%
|
|
1/25/2012
|
Popovits Kimberly J
|
President and CEO
|
-5,000
|
$26.42
|
-1.80%
|
|
1/24/2012
|
Shak Steven
|
Chief Medical Officer
|
-5,000
|
$26.74
|
-1.29%
|
|
1/24/2012
|
Popovits Kimberly J
|
President and CEO
|
-5,000
|
$26.62
|
-1.76%
|
|
1/17/2012
|
Schorno Dean L
|
CFO
|
-1,000
|
$28.00
|
-5.29%
|
|
1/12/2012
|
Cole G Bradley
|
COO
|
-2,500
|
$27.54
|
-24.39%
|
|
1/12/2012
|
Cole G Bradley
|
COO
|
2,500
|
$1.33
|
32.26%
|
|
1/11/2012
|
Scott Randal W
|
Executive Chairman
|
-9,900
|
$27.55
|
-0.73%
|
|
1/11/2012
|
Scott Randal W
|
Executive Chairman
|
-100
|
$28.23
|
-0.01%
|
|
1/10/2012
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$27.35
|
-0.73%
|
|
1/1/2012
|
Cohen Fred E
|
Director
|
393
|
$25.39
|
0.79%
|
|
1/1/2012
|
GRAHAM GINGER L
|
Director
|
393
|
$25.39
|
32.27%
|
|
1/1/2012
|
MYERS WOODROW A JR
|
Director
|
393
|
$25.39
|
32.27%
|
|
1/1/2012
|
COLELLA SAMUEL D
|
Director
|
393
|
$25.39
|
32.27%
|
|
12/22/2011
|
Shak Steven
|
Chief Medical Officer
|
-5,000
|
$26.03
|
-1.27%
|
|
12/13/2011
|
Scott Randal W
|
Executive Chairman
|
-2,110
|
$27.50
|
-0.15%
|
|
12/13/2011
|
Scott Randal W
|
Executive Chairman
|
-7,890
|
$26.88
|
-0.58%
|
|
12/12/2011
|
Scott Randal W
|
Executive Chairman
|
-100
|
$28.46
|
-0.01%
|
|
12/12/2011
|
Scott Randal W
|
Executive Chairman
|
-9,900
|
$27.56
|
-0.72%
|
|
12/6/2011
|
Cole G Bradley
|
COO
|
2,500
|
$1.33
|
32.26%
|
|
12/6/2011
|
Cole G Bradley
|
COO
|
-2,500
|
$28.59
|
-24.39%
|
|
12/5/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
323
|
$28.50
|
0.17%
|
|
12/5/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
225
|
$28.39
|
0.12%
|
|
12/5/2011
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
1,992
|
$28.50
|
0.15%
|
|
12/5/2011
|
Baker Biotech Capital (GP), LLC
|
Senior Executive Officer
|
1,385
|
$28.39
|
0.11%
|
|
12/5/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
12,066
|
$28.50
|
0.18%
|
|
12/5/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
8,390
|
$28.39
|
0.12%
|
|
12/2/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
639
|
$28.04
|
0.34%
|