|
Date |
Name |
Title |
Volume |
Trade Price |
Holding Change |
|
7/6/2011
|
Cole G Bradley
|
COO
|
5,000
|
$1.33
|
64.52%
|
|
7/6/2011
|
Cole G Bradley
|
COO
|
-5,000
|
$27.74
|
-39.22%
|
|
7/1/2011
|
Cohen Fred E
|
Director
|
358
|
$27.91
|
0.73%
|
|
7/1/2011
|
COLELLA SAMUEL D
|
Director
|
358
|
$27.91
|
88.18%
|
|
7/1/2011
|
GRAHAM GINGER L
|
Director
|
358
|
$27.91
|
88.18%
|
|
7/1/2011
|
MYERS WOODROW A JR
|
Director
|
358
|
$27.91
|
88.18%
|
|
6/23/2011
|
Shak Steven
|
Chief Medical Officer
|
5,000
|
$9.39
|
1.27%
|
|
6/23/2011
|
Shak Steven
|
Chief Medical Officer
|
-5,000
|
$27.12
|
-1.26%
|
|
6/15/2011
|
Schorno Dean L
|
CFO
|
-1,000
|
$25.91
|
-5.03%
|
|
6/13/2011
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$25.37
|
-0.66%
|
|
6/10/2011
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$26.01
|
-0.65%
|
|
6/9/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
35
|
$26.35
|
0.02%
|
|
6/9/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
82,031
|
$26.25
|
1.37%
|
|
6/9/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
5,996
|
$26.30
|
0.10%
|
|
6/9/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
1,864
|
$26.35
|
0.03%
|
|
6/9/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
112
|
$26.30
|
0.07%
|
|
6/9/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,524
|
$26.25
|
0.95%
|
|
6/9/2011
|
Baker Bros. Capital (GP), LLC
|
Senior Executive Officer
|
45
|
$26.25
|
0.02%
|
|
6/8/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
24,402
|
$26.15
|
0.41%
|
|
6/8/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
8,746
|
$26.11
|
0.15%
|
|
6/8/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
11,415
|
$26.10
|
0.19%
|
|
6/8/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
583
|
$26.15
|
0.37%
|
|
6/8/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
209
|
$26.11
|
0.13%
|
|
6/8/2011
|
Baker Bros. Capital (GP), LLC
|
Senior Executive Officer
|
15
|
$26.15
|
0.01%
|
|
6/8/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
273
|
$26.10
|
0.17%
|
|
6/7/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,045
|
$26.17
|
0.66%
|
|
6/7/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
43,763
|
$26.17
|
0.75%
|
|
6/7/2011
|
Baker Bros. Capital (GP), LLC
|
Senior Executive Officer
|
16
|
$26.14
|
0.01%
|
|
6/7/2011
|
Baker Bros. Capital (GP), LLC
|
Senior Executive Officer
|
27
|
$26.17
|
0.01%
|
|
6/7/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
607
|
$26.14
|
0.38%
|
|
6/7/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
25,435
|
$26.14
|
0.43%
|
|
6/6/2011
|
Cole G Bradley
|
COO
|
2,500
|
$1.33
|
32.26%
|
|
6/6/2011
|
Cole G Bradley
|
COO
|
-2,500
|
$26.18
|
-24.39%
|
|
6/1/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
34,379
|
$27.51
|
0.59%
|
|
6/1/2011
|
Baker Bros. Capital (GP), LLC
|
Senior Executive Officer
|
23
|
$27.47
|
0.01%
|
|
6/1/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
821
|
$27.51
|
0.52%
|
|
6/1/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
885
|
$27.47
|
0.57%
|
|
6/1/2011
|
Baker Bros. Capital (GP), LLC
|
Senior Executive Officer
|
21
|
$27.51
|
0.01%
|
|
6/1/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
37,092
|
$27.47
|
0.64%
|
|
5/31/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
957
|
$27.48
|
0.62%
|
|
5/31/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
504
|
$27.46
|
0.33%
|
|
5/31/2011
|
Baker Bros. Capital (GP), LLC
|
Senior Executive Officer
|
22
|
$27.48
|
0.01%
|
|
5/31/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
18,983
|
$27.46
|
0.33%
|
|
5/31/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
36,056
|
$27.48
|
0.63%
|
|
5/31/2011
|
Baker Bros. Capital (GP), LLC
|
Senior Executive Officer
|
12
|
$27.46
|
0.01%
|
|
5/27/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,464
|
$27.04
|
0.96%
|
|
5/27/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
55,183
|
$27.04
|
0.97%
|
|
5/27/2011
|
Baker Bros. Capital (GP), LLC
|
Senior Executive Officer
|
34
|
$27.04
|
0.02%
|
|
5/25/2011
|
Shak Steven
|
Chief Medical Officer
|
5,000
|
$9.39
|
1.27%
|
|
5/25/2011
|
Shak Steven
|
Chief Medical Officer
|
-5,000
|
$25.56
|
-1.26%
|
|
5/12/2011
|
Schorno Dean L
|
CFO
|
-1,000
|
$26.48
|
-4.78%
|
|
5/11/2011
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$26.72
|
-0.65%
|
|
5/10/2011
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$26.59
|
-0.64%
|
|
5/9/2011
|
Cole G Bradley
|
COO
|
-2,500
|
$25.93
|
-24.39%
|
|
5/9/2011
|
Cole G Bradley
|
COO
|
2,500
|
$1.33
|
32.26%
|
|
4/27/2011
|
LIVINGSTON RANDALL S
|
Director
|
2,000
|
$1.33
|
32.53%
|
|
4/27/2011
|
LIVINGSTON RANDALL S
|
Director
|
-2,000
|
$26.04
|
-24.54%
|
|
4/25/2011
|
Shak Steven
|
Chief Medical Officer
|
-5,000
|
$25.38
|
-1.26%
|
|
4/25/2011
|
Shak Steven
|
Chief Medical Officer
|
5,000
|
$9.39
|
1.27%
|
|
4/15/2011
|
Popovits Kimberly J
|
President and CEO
|
4,000
|
$9.39
|
40.00%
|
|
4/15/2011
|
Popovits Kimberly J
|
President and CEO
|
-4,000
|
$25.64
|
-28.57%
|
|
4/14/2011
|
Popovits Kimberly J
|
President and CEO
|
-4,000
|
$25.33
|
-28.57%
|
|
4/14/2011
|
Schorno Dean L
|
CFO
|
-1,000
|
$25.32
|
-4.57%
|
|
4/14/2011
|
Popovits Kimberly J
|
President and CEO
|
4,000
|
$9.39
|
40.00%
|
|
4/12/2011
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$25.92
|
-0.64%
|
|
4/11/2011
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$26.01
|
-0.63%
|
|
4/6/2011
|
Cole G Bradley
|
COO
|
-5,000
|
$26.91
|
-39.22%
|
|
4/6/2011
|
Cole G Bradley
|
COO
|
5,000
|
$1.33
|
64.52%
|
|
4/1/2011
|
Cohen Fred E
|
Director
|
406
|
$24.60
|
0.83%
|
|
3/24/2011
|
Shak Steven
|
Chief Medical Officer
|
5,000
|
$9.39
|
1.27%
|
|
3/24/2011
|
Shak Steven
|
Chief Medical Officer
|
-5,000
|
$24.45
|
-1.26%
|
|
3/15/2011
|
Popovits Kimberly J
|
President and CEO
|
4,000
|
$9.39
|
40.00%
|
|
3/15/2011
|
Popovits Kimberly J
|
President and CEO
|
-4,000
|
$23.81
|
-28.57%
|
|
3/15/2011
|
Schorno Dean L
|
CFO
|
-1,000
|
$23.79
|
-4.37%
|
|
3/15/2011
|
Popovits Kimberly J
|
President and CEO
|
4,000
|
$9.39
|
1.35%
|
|
3/15/2011
|
Popovits Kimberly J
|
President and CEO
|
-4,000
|
$23.81
|
-1.33%
|
|
3/14/2011
|
Popovits Kimberly J
|
President and CEO
|
-4,000
|
$24.77
|
-1.33%
|
|
3/14/2011
|
Popovits Kimberly J
|
President and CEO
|
4,000
|
$9.39
|
1.35%
|
|
3/14/2011
|
Popovits Kimberly J
|
President and CEO
|
-4,000
|
$24.77
|
-28.57%
|
|
3/14/2011
|
Popovits Kimberly J
|
President and CEO
|
4,000
|
$9.39
|
40.00%
|
|
3/11/2011
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$25.64
|
-0.63%
|
|
3/10/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
20,000
|
$25.56
|
0.35%
|
|
3/10/2011
|
Scott Randal W
|
Executive Chairman
|
-10,000
|
$25.61
|
-0.62%
|
|
3/9/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
49,056
|
$26.22
|
0.88%
|
|
3/9/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
1,800
|
$26.17
|
0.03%
|
|
3/8/2011
|
Cole G Bradley
|
COO
|
-2,500
|
$25.23
|
-24.39%
|
|
3/8/2011
|
Cole G Bradley
|
COO
|
2,500
|
$1.33
|
32.26%
|
|
3/8/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
1,826
|
$25.13
|
0.03%
|
|
3/8/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
50
|
$25.13
|
0.03%
|
|
3/7/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
955
|
$25.39
|
0.66%
|
|
3/7/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
537
|
$25.40
|
0.37%
|
|
3/7/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
6,715
|
$24.90
|
4.60%
|
|
3/7/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
243,285
|
$24.90
|
4.54%
|
|
3/7/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
34,592
|
$25.39
|
0.65%
|
|
3/7/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
19,463
|
$25.40
|
0.37%
|
|
3/4/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
41,041
|
$25.44
|
0.78%
|
|
3/4/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
Senior Executive Officer
|
9,359
|
$25.50
|
0.18%
|
|
3/4/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
1,133
|
$25.44
|
0.79%
|
|
3/4/2011
|
14159 capital (GP), LLC
|
Senior Executive Officer
|
258
|
$25.50
|
0.18%
|
|
3/3/2011
|
COLELLA SAMUEL D
|
Director
|
-10,571
|
$25.45
|
-35.32%
|