|
Date |
Name |
Title |
Volume |
Trade Price |
Holding Change |
|
5/10/2013
|
Berkman Charles S
|
VP, Gen. Counsel & Secretary
|
-4,000
|
$26.66
|
-23.77%
|
|
1/23/2013
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
39,600
|
$19.78
|
1.86%
|
|
12/31/2012
|
DeSilva Nishan M
|
VP, Corporate Development
|
490
|
$14.54
|
4.90%
|
|
12/21/2012
|
KOZARICH JOHN W
|
Director
|
3,333
|
$12.06
|
9.92%
|
|
12/14/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
5,386
|
$18.63
|
0.25%
|
|
12/6/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
50,100
|
$17.94
|
2.42%
|
|
12/5/2012
|
HIGGINS JOHN L
|
President & CEO
|
2,000
|
$18.03
|
1.82%
|
|
12/5/2012
|
FOEHR MATTHEW W
|
EVP and COO
|
370
|
$17.99
|
0.99%
|
|
11/30/2012
|
KNOTT DAVID M
|
Director
|
-6,652
|
$19.71
|
-3.05%
|
|
11/29/2012
|
KNOTT DAVID M
|
Director
|
-13,348
|
$20.00
|
-5.77%
|
|
11/28/2012
|
KNOTT DAVID M
|
Director
|
-35,000
|
$19.51
|
-13.14%
|
|
11/27/2012
|
KNOTT DAVID M
|
Director
|
-65,000
|
$19.55
|
-19.61%
|
|
10/31/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
4,076
|
$14.99
|
0.55%
|
|
10/26/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
12,515
|
$15.26
|
1.73%
|
|
9/7/2012
|
Berkman Charles S
|
VP, Gen. Counsel & Secretary
|
-4,249
|
$18.77
|
-22.87%
|
|
8/13/2012
|
HIGGINS JOHN L
|
President & CEO
|
500
|
$16.39
|
0.46%
|
|
6/29/2012
|
FOEHR MATTHEW W
|
EVP and COO
|
1,250
|
$10.12
|
3.45%
|
|
6/29/2012
|
HIGGINS JOHN L
|
President & CEO
|
1,250
|
$10.12
|
1.15%
|
|
6/29/2012
|
Berkman Charles S
|
VP, Gen. Counsel & Secretary
|
1,250
|
$10.12
|
7.21%
|
|
6/1/2012
|
Sabba Stephen L
|
Director
|
2,000
|
$12.02
|
12.97%
|
|
6/1/2012
|
Aryeh Jason
|
Director
|
700
|
$11.98
|
0.25%
|
|
5/24/2012
|
KNOTT DAVID M
|
Director
|
23,900
|
$11.62
|
9.93%
|
|
5/24/2012
|
KNOTT DAVID M
|
Director
|
-21,200
|
$11.62
|
-33.77%
|
|
5/24/2012
|
KNOTT DAVID M
|
Director
|
-76,167
|
$11.62
|
-18.69%
|
|
5/24/2012
|
KNOTT DAVID M
|
Director
|
-98,633
|
$11.62
|
-100.00%
|
|
5/24/2012
|
KNOTT DAVID M
|
Director
|
172,100
|
$11.62
|
21.51%
|
|
5/23/2012
|
Patel Sunil
|
Director
|
100
|
$11.35
|
0.35%
|
|
5/23/2012
|
Patel Sunil
|
Director
|
1,249
|
$11.39
|
4.39%
|
|
5/23/2012
|
Patel Sunil
|
Director
|
20
|
$11.35
|
0.07%
|
|
5/23/2012
|
Patel Sunil
|
Director
|
100
|
$11.35
|
0.35%
|
|
5/23/2012
|
Patel Sunil
|
Director
|
31
|
$11.37
|
0.11%
|
|
5/4/2012
|
HIGGINS JOHN L
|
President & CEO
|
1,000
|
$12.04
|
0.93%
|
|
3/8/2012
|
Berkman Charles S
|
VP, Gen. Counsel & Secretary
|
-106
|
$15.77
|
-0.61%
|
|
3/8/2012
|
Berkman Charles S
|
VP, Gen. Counsel & Secretary
|
-3,500
|
$15.76
|
-16.72%
|
|
11/21/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
280,100
|
$10.59
|
15.66%
|
|
11/21/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
60,100
|
$10.59
|
15.65%
|
|
11/21/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
98,171
|
$10.59
|
15.66%
|
|
11/18/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
46,426
|
$11.01
|
2.67%
|
|
11/18/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
9,951
|
$11.01
|
2.66%
|
|
11/18/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
16,292
|
$11.01
|
2.67%
|
|
11/14/2011
|
Sabba Stephen L
|
Director
|
1,000
|
$11.50
|
8.54%
|
|
11/10/2011
|
Sabba Stephen L
|
Director
|
1,000
|
$11.69
|
9.34%
|
|
11/10/2011
|
KNOTT DAVID M
|
Director
|
4,000
|
$11.58
|
7.89%
|
|
10/26/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
3,800
|
$13.91
|
0.22%
|
|
10/26/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
900
|
$13.91
|
0.24%
|
|
10/26/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
1,320
|
$13.91
|
0.22%
|
|
10/21/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
3,000
|
$13.93
|
0.17%
|
|
10/21/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
1,000
|
$13.93
|
0.16%
|
|
10/21/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
600
|
$13.93
|
0.16%
|
|
10/20/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
7,600
|
$13.93
|
0.44%
|
|
10/20/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
1,600
|
$13.93
|
0.43%
|
|
10/20/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
2,700
|
$13.93
|
0.45%
|
|
10/18/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
1,400
|
$13.73
|
0.08%
|
|
10/18/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
300
|
$13.73
|
0.08%
|
|
10/18/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
500
|
$13.73
|
0.08%
|
|
10/13/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
4,995
|
$13.55
|
0.83%
|
|
10/13/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
3,020
|
$13.55
|
0.82%
|
|
10/13/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
14,238
|
$13.55
|
0.83%
|
|
10/12/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
36,200
|
$13.69
|
2.16%
|
|
10/12/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
5,600
|
$13.69
|
1.55%
|
|
10/12/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
11,300
|
$13.69
|
1.92%
|
|
10/4/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
4,300
|
$12.78
|
1.20%
|
|
10/4/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
4,000
|
$12.78
|
0.24%
|
|
10/4/2011
|
BVF PARTNERS L P/IL
|
TenPercent
|
6,100
|
$12.78
|
1.05%
|
|
9/1/2011
|
KNOTT DAVID M
|
Director
|
5,320
|
$15.21
|
0.67%
|
|
9/1/2011
|
KNOTT DAVID M
|
Director
|
1,500
|
$15.21
|
0.63%
|
|
9/1/2011
|
KNOTT DAVID M
|
Director
|
2,480
|
$15.21
|
0.61%
|
|
9/1/2011
|
KNOTT DAVID M
|
Director
|
700
|
$15.21
|
0.71%
|
|
8/31/2011
|
KNOTT DAVID M
|
Director
|
600
|
$14.94
|
0.15%
|
|
8/31/2011
|
KNOTT DAVID M
|
Director
|
200
|
$14.94
|
0.20%
|
|
8/31/2011
|
KNOTT DAVID M
|
Director
|
1,700
|
$14.94
|
0.21%
|
|
8/31/2011
|
KNOTT DAVID M
|
Director
|
500
|
$14.94
|
0.21%
|
|
8/30/2011
|
KNOTT DAVID M
|
Director
|
1,640
|
$14.83
|
0.41%
|
|
8/30/2011
|
KNOTT DAVID M
|
Director
|
5,200
|
$14.83
|
0.66%
|
|
8/30/2011
|
KNOTT DAVID M
|
Director
|
700
|
$14.83
|
0.72%
|
|
8/30/2011
|
KNOTT DAVID M
|
Director
|
1,400
|
$14.83
|
0.59%
|
|
8/29/2011
|
KNOTT DAVID M
|
Director
|
10,400
|
$14.21
|
1.34%
|
|
8/29/2011
|
KNOTT DAVID M
|
Director
|
1,200
|
$14.21
|
1.25%
|
|
8/29/2011
|
KNOTT DAVID M
|
Director
|
3,100
|
$14.21
|
1.32%
|
|
8/29/2011
|
KNOTT DAVID M
|
Director
|
5,300
|
$14.21
|
1.33%
|
|
8/26/2011
|
KNOTT DAVID M
|
Director
|
11,159
|
$12.54
|
2.89%
|
|
8/26/2011
|
KNOTT DAVID M
|
Director
|
2,600
|
$12.54
|
2.79%
|
|
8/26/2011
|
KNOTT DAVID M
|
Director
|
6,600
|
$12.54
|
2.90%
|
|
8/26/2011
|
KNOTT DAVID M
|
Director
|
21,200
|
$12.54
|
2.80%
|
|
8/25/2011
|
KNOTT DAVID M
|
Director
|
17,200
|
$12.57
|
37.73%
|
|
8/25/2011
|
KNOTT DAVID M
|
Director
|
9,900
|
$12.57
|
2.63%
|
|
8/25/2011
|
KNOTT DAVID M
|
Director
|
2,500
|
$12.57
|
2.76%
|
|
8/25/2011
|
KNOTT DAVID M
|
Director
|
5,800
|
$12.57
|
2.61%
|
|
8/25/2011
|
KNOTT DAVID M
|
Director
|
19,600
|
$12.57
|
2.66%
|
|
8/24/2011
|
KNOTT DAVID M
|
Director
|
7,500
|
$12.95
|
1.03%
|
|
8/24/2011
|
KNOTT DAVID M
|
Director
|
2,390
|
$12.95
|
1.09%
|
|
8/24/2011
|
KNOTT DAVID M
|
Director
|
900
|
$12.95
|
1.00%
|
|
8/24/2011
|
KNOTT DAVID M
|
Director
|
4,100
|
$12.95
|
9.88%
|
|
8/24/2011
|
KNOTT DAVID M
|
Director
|
2,600
|
$12.95
|
10.12%
|
|
8/24/2011
|
KNOTT DAVID M
|
Director
|
4,000
|
$12.95
|
1.07%
|
|
8/23/2011
|
KNOTT DAVID M
|
Director
|
5,400
|
$12.18
|
1.47%
|
|
8/23/2011
|
KNOTT DAVID M
|
Director
|
1,200
|
$12.18
|
1.35%
|
|
8/23/2011
|
KNOTT DAVID M
|
Director
|
10,300
|
$12.18
|
1.43%
|
|
8/23/2011
|
KNOTT DAVID M
|
Director
|
3,100
|
$12.18
|
1.43%
|
|
8/22/2011
|
KNOTT DAVID M
|
Director
|
1,069
|
$12.00
|
0.29%
|