|
Date |
Name |
Title |
Volume |
Trade Price |
Holding Change |
|
4/24/2013
|
EVNIN LUKE
|
Director
|
-6,303
|
$30.04
|
-0.54%
|
|
4/24/2013
|
Wicki Andreas
|
Director
|
-401
|
$30.04
|
-0.02%
|
|
4/23/2013
|
Wicki Andreas
|
Director
|
-15,646
|
$30.00
|
-0.71%
|
|
4/23/2013
|
EVNIN LUKE
|
Director
|
-108,115
|
$30.00
|
-8.46%
|
|
4/15/2013
|
EVNIN LUKE
|
Director
|
-2,575
|
$30.00
|
-0.20%
|
|
4/15/2013
|
Wicki Andreas
|
Director
|
-6,400
|
$30.00
|
-0.29%
|
|
4/12/2013
|
Wicki Andreas
|
Director
|
-34,294
|
$30.00
|
-1.54%
|
|
4/12/2013
|
EVNIN LUKE
|
Director
|
-10,000
|
$30.00
|
-0.77%
|
|
4/12/2013
|
PATOU GARY
|
Chief Medical Officer
|
-10,000
|
$30.00
|
-100.00%
|
|
4/11/2013
|
Wicki Andreas
|
Director
|
-600
|
$30.00
|
-0.03%
|
|
4/1/2013
|
PATOU GARY
|
Chief Medical Officer
|
-18,700
|
$27.75
|
-62.33%
|
|
4/1/2013
|
PATOU GARY
|
Chief Medical Officer
|
-11,300
|
$28.82
|
-100.00%
|
|
3/28/2013
|
Scibetta James S
|
Chief Financial Officer
|
10,000
|
$1.61
|
200.00%
|
|
3/28/2013
|
LONGENECKER JOHN P PHD
|
Director
|
-2,000
|
$28.49
|
-100.00%
|
|
3/28/2013
|
STACK DAVID M
|
President and CEO
|
-15,000
|
$28.66
|
-85.36%
|
|
3/28/2013
|
STACK DAVID M
|
President and CEO
|
15,000
|
$1.61
|
582.98%
|
|
3/28/2013
|
Scibetta James S
|
Chief Financial Officer
|
-10,000
|
$28.49
|
-66.67%
|
|
3/25/2013
|
HBM Healthcare Investments (Cayman) Ltd.
|
Substantial Shareholder
|
-165,541
|
$28.28
|
-6.90%
|
|
3/25/2013
|
Wicki Andreas
|
Director
|
-165,541
|
$28.28
|
-6.90%
|
|
3/22/2013
|
Wicki Andreas
|
Director
|
-113,928
|
$27.52
|
-4.53%
|
|
3/22/2013
|
HBM Healthcare Investments (Cayman) Ltd.
|
Substantial Shareholder
|
-113,928
|
$27.52
|
-4.53%
|
|
3/21/2013
|
HBM Healthcare Investments (Cayman) Ltd.
|
Substantial Shareholder
|
-11,431
|
$27.50
|
-0.45%
|
|
3/21/2013
|
Wicki Andreas
|
Director
|
-11,431
|
$27.50
|
-0.45%
|
|
3/19/2013
|
HBM BIOVENTURES CAYMAN LTD
|
Substantial Shareholder
|
-9,100
|
$27.86
|
-0.36%
|
|
3/19/2013
|
Wicki Andreas
|
Director
|
-9,100
|
$27.86
|
-0.36%
|
|
3/19/2013
|
Sanderling Venture Partners VI LP
|
Director
|
-46,339
|
$26.95
|
-10.02%
|
|
3/19/2013
|
Sanderling Venture Partners VI LP
|
Director
|
-38,250
|
$27.66
|
-7.64%
|
|
3/18/2013
|
Wicki Andreas
|
Director
|
-400,000
|
$28.19
|
-13.63%
|
|
3/18/2013
|
HBM BIOVENTURES CAYMAN LTD
|
Substantial Shareholder
|
-400,000
|
$28.19
|
-13.63%
|
|
3/18/2013
|
Sanderling Venture Partners VI LP
|
Director
|
-29,415
|
$28.19
|
-100.00%
|
|
3/18/2013
|
Sanderling Venture Partners VI LP
|
Director
|
-29,825
|
$28.19
|
-5.62%
|
|
3/18/2013
|
EVNIN LUKE
|
Director
|
-500,000
|
$28.44
|
-17.92%
|
|
3/18/2013
|
Sanderling Venture Partners VI LP
|
Director
|
-28,956
|
$29.20
|
-5.18%
|
|
3/18/2013
|
Sanderling Venture Partners VI LP
|
Director
|
-23,969
|
$29.20
|
-49.26%
|
|
3/18/2013
|
Sanderling Venture Partners VI LP
|
Director
|
-28,558
|
$29.20
|
-49.26%
|
|
3/18/2013
|
Sanderling Venture Partners VI LP
|
Director
|
-24,688
|
$28.19
|
-100.00%
|
|
3/14/2013
|
Riker Lauren Bullaro
|
Executive Director, Accounting
|
-10,000
|
$30.00
|
-83.33%
|
|
3/14/2013
|
Riker Lauren Bullaro
|
Executive Director, Accounting
|
10,000
|
$10.34
|
500.00%
|
|
3/12/2013
|
Pratt John
|
General Manager, San Diego
|
-9,375
|
$28.46
|
-100.00%
|
|
3/11/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-348,951
|
$27.86
|
-38.41%
|
|
3/11/2013
|
EVNIN LUKE
|
Director
|
-500,000
|
$27.86
|
-15.20%
|
|
3/11/2013
|
MPM BioVentures IV QP LP
|
N/A
|
-500,000
|
$27.86
|
-15.20%
|
|
3/11/2013
|
KAILIAN VAUGHN M
|
N/A
|
-500,000
|
$27.86
|
-15.20%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-66
|
$25.92
|
-0.14%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
20,069
|
$13.44
|
1.48%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
843
|
$13.44
|
1.46%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
708
|
$13.44
|
1.47%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-78
|
$25.92
|
-0.14%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
629
|
$2.69
|
1.32%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-1,866
|
$25.92
|
-0.21%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
750
|
$2.69
|
1.32%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
17,839
|
$2.69
|
1.34%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
17,973
|
$2.69
|
2.04%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
20,220
|
$13.44
|
2.25%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-1,852
|
$25.92
|
-0.14%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-10,485
|
$25.92
|
-1.14%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-368
|
$25.92
|
-0.75%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-438
|
$25.92
|
-0.75%
|
|
3/7/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-10,407
|
$25.92
|
-0.76%
|
|
1/24/2013
|
Sanderling Venture Partners VI LP
|
Substantial Shareholder
|
-500,000
|
$18.93
|
-36.16%
|
|
4/17/2012
|
PACE GARY W
|
Director
|
10,000
|
$9.75
|
130.01%
|
|
3/12/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-62,400
|
$11.03
|
-2.49%
|
|
3/12/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-700
|
$11.03
|
-0.03%
|
|
3/9/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-300
|
$11.25
|
-0.01%
|
|
3/9/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-36,700
|
$11.25
|
-1.44%
|
|
2/29/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-3,000
|
$10.86
|
-0.12%
|
|
2/28/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-10,000
|
$11.12
|
-0.39%
|
|
2/27/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-28,700
|
$11.05
|
-1.11%
|
|
2/27/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-300
|
$11.05
|
-0.01%
|
|
2/8/2012
|
KAILIAN VAUGHN M
|
TenPercent
|
267,857
|
$7.00
|
10.46%
|
|
2/8/2012
|
EVNIN LUKE
|
Senior Executive Officer
|
267,857
|
$7.00
|
10.46%
|
|
2/8/2012
|
MPM BioVentures IV QP LP
|
TenPercent
|
267,857
|
$7.00
|
10.46%
|
|
2/3/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-500
|
$10.79
|
-0.02%
|
|
2/3/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-49,500
|
$10.79
|
-1.88%
|
|
2/2/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-23,100
|
$10.86
|
-0.87%
|
|
2/2/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-200
|
$10.86
|
-0.01%
|
|
2/1/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-700
|
$11.01
|
-0.03%
|
|
2/1/2012
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-69,300
|
$11.01
|
-2.54%
|
|
11/21/2011
|
Wicki Andreas
|
Director
|
307,692
|
$6.50
|
9.81%
|
|
11/21/2011
|
MPM BioVentures IV QP LP
|
TenPercent
|
461,538
|
$6.50
|
16.31%
|
|
11/21/2011
|
KAILIAN VAUGHN M
|
TenPercent
|
461,538
|
$6.50
|
16.31%
|
|
11/21/2011
|
EVNIN LUKE
|
Senior Executive Officer
|
461,538
|
$6.50
|
16.31%
|
|
11/21/2011
|
HBM BIOVENTURES CAYMAN LTD
|
TenPercent
|
307,692
|
$6.50
|
9.81%
|
|
10/31/2011
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-96,554
|
$10.53
|
-3.41%
|
|
10/31/2011
|
ORBIMED ADVISORS LLC
|
TenPercent
|
-887
|
$10.53
|
-0.03%
|
|
2/10/2011
|
STACK DAVID M
|
President and CEO
|
5,000
|
$6.60
|
26.88%
|
|
2/8/2011
|
GORDON CARL L
|
Director
|
2,527
|
$7.00
|
0.09%
|
|
2/8/2011
|
ORBIMED ADVISORS LLC
|
TenPercent
|
705,845
|
$13.44
|
44.66%
|
|
2/8/2011
|
ORBIMED ADVISORS LLC
|
TenPercent
|
6,722
|
$13.44
|
0.29%
|
|
2/8/2011
|
ORBIMED ADVISORS LLC
|
TenPercent
|
265,331
|
$7.00
|
11.57%
|
|
2/8/2011
|
ORBIMED ADVISORS LLC
|
TenPercent
|
2,526
|
$7.00
|
0.10%
|
|
2/8/2011
|
ORBIMED ADVISORS LLC
|
TenPercent
|
265,330
|
$7.00
|
10.36%
|
|
2/8/2011
|
ORBIMED ADVISORS LLC
|
TenPercent
|
2,527
|
$7.00
|
0.09%
|
|
2/8/2011
|
GORDON CARL L
|
Director
|
265,330
|
$7.00
|
10.36%
|
|
2/8/2011
|
GORDON CARL L
|
Director
|
265,331
|
$7.00
|
11.57%
|
|
2/8/2011
|
MPM BioVentures IV QP LP
|
TenPercent
|
267,857
|
$7.00
|
10.46%
|
|
2/8/2011
|
EVNIN LUKE
|
Senior Executive Officer
|
267,857
|
$7.00
|
10.46%
|
|
2/8/2011
|
KAILIAN VAUGHN M
|
TenPercent
|
267,857
|
$7.00
|
10.46%
|
|
2/8/2011
|
Wicki Andreas
|
Director
|
267,857
|
$7.00
|
9.33%
|
|
2/8/2011
|
Wicki Andreas
|
Director
|
1,021,223
|
$13.44
|
64.61%
|