|
Date |
Name |
Title |
Volume |
Trade Price |
Holding Change |
|
3/11/2013
|
HILL STEPHEN A
|
President and CEO
|
10,000
|
$4.38
|
100.00%
|
|
11/19/2012
|
SANDELL SCOTT D
|
Substantial Shareholder
|
3,333
|
$0.08
|
166.65%
|
|
11/19/2012
|
KRAMLICH C RICHARD
|
Substantial Shareholder
|
3,333
|
$0.08
|
166.65%
|
|
11/19/2012
|
BARRIS PETER J
|
Substantial Shareholder
|
3,333
|
$0.08
|
166.65%
|
|
11/16/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
378,000
|
$4.00
|
14.54%
|
|
11/16/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
26,800
|
$5.11
|
1.79%
|
|
11/16/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
46,700
|
$5.11
|
1.80%
|
|
11/16/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
217,000
|
$4.00
|
14.50%
|
|
11/14/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
444,649
|
$4.00
|
42.26%
|
|
11/14/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
772,063
|
$4.00
|
42.24%
|
|
11/8/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
17,400
|
$4.01
|
1.68%
|
|
11/8/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
31,929
|
$4.01
|
1.78%
|
|
11/7/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
8,800
|
$4.08
|
0.86%
|
|
11/7/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
14,300
|
$4.08
|
0.80%
|
|
11/2/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
21,500
|
$4.05
|
2.14%
|
|
11/2/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
36,100
|
$4.05
|
2.07%
|
|
11/1/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
6,700
|
$4.05
|
0.39%
|
|
11/1/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
23,400
|
$4.05
|
2.38%
|
|
10/31/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
46,700
|
$4.06
|
2.76%
|
|
10/31/2012
|
BVF PARTNERS L P/IL
|
Substantial Shareholder
|
5,300
|
$4.06
|
0.54%
|
|
7/1/2011
|
Richard John P
|
Director
|
-2,500
|
$21.02
|
-31.92%
|
|
7/1/2011
|
Richard John P
|
Director
|
2,500
|
$9.27
|
46.88%
|
|
6/7/2011
|
Musso Alan A
|
SVP, CFO & Treasurer
|
11,627
|
$5.10
|
415.40%
|
|
6/7/2011
|
Musso Alan A
|
SVP, CFO & Treasurer
|
2,880
|
$5.63
|
19.96%
|
|
6/7/2011
|
Musso Alan A
|
SVP, CFO & Treasurer
|
16,368
|
$5.55
|
94.58%
|
|
6/7/2011
|
Musso Alan A
|
SVP, CFO & Treasurer
|
-30,875
|
$21.80
|
-91.69%
|
|
5/13/2011
|
BROWN JULIA R
|
Director
|
-9,100
|
$23.38
|
-100.00%
|
|
5/12/2011
|
BURRILL STEVEN
|
Director
|
7,500
|
$7.10
|
41.55%
|
|
5/12/2011
|
BURRILL STEVEN
|
Director
|
7,500
|
$9.27
|
71.08%
|
|
5/12/2011
|
BURRILL STEVEN
|
Director
|
-33,052
|
$23.88
|
-100.00%
|
|
5/12/2011
|
BURRILL STEVEN
|
Director
|
7,500
|
$2.71
|
29.35%
|
|
5/11/2011
|
BURRILL STEVEN
|
Director
|
7,500
|
$9.27
|
71.08%
|
|
5/11/2011
|
BURRILL STEVEN
|
Director
|
7,500
|
$2.71
|
29.35%
|
|
5/11/2011
|
BURRILL STEVEN
|
Director
|
7,500
|
$7.10
|
41.55%
|
|
5/11/2011
|
BURRILL STEVEN
|
Director
|
-33,052
|
$23.88
|
-100.00%
|
|
5/10/2011
|
BURRILL STEVEN
|
Director
|
-16,948
|
$24.04
|
-100.00%
|
|
5/10/2011
|
BURRILL STEVEN
|
Director
|
-2,000
|
$24.13
|
-100.00%
|
|
5/10/2011
|
BURRILL STEVEN
|
Director
|
-16,948
|
$24.04
|
-100.00%
|
|
5/10/2011
|
BURRILL STEVEN
|
Director
|
-2,000
|
$24.13
|
-100.00%
|
|
4/1/2011
|
Richard John P
|
Director
|
2,500
|
$9.27
|
46.88%
|
|
4/1/2011
|
Richard John P
|
Director
|
-2,500
|
$26.60
|
-31.92%
|
|
3/31/2011
|
Caldwell William S
|
SVP - Drug Discovery and Dev.
|
-2,655
|
$26.37
|
-25.55%
|
|
3/31/2011
|
Caldwell William S
|
SVP - Drug Discovery and Dev.
|
2,655
|
$2.93
|
34.32%
|
|
3/9/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
-1,500
|
$30.00
|
-56.41%
|
|
3/9/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
1,500
|
$5.55
|
129.42%
|
|
3/7/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
-500
|
$30.00
|
-30.14%
|
|
3/7/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
500
|
$5.55
|
43.14%
|
|
3/3/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
-5,030
|
$30.00
|
-81.27%
|
|
3/3/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
5,030
|
$5.55
|
433.99%
|
|
3/2/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
-200
|
$30.00
|
-14.72%
|
|
3/2/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
200
|
$5.55
|
17.26%
|
|
3/1/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
12,703
|
$5.55
|
1,096.03%
|
|
3/1/2011
|
Caldwell William S
|
SVP - Drug Discovery and Dev.
|
11,360
|
$8.51
|
146.86%
|
|
3/1/2011
|
Hodges Mauri K
|
VP Fin + Corp Sys & Controller
|
-12,703
|
$30.16
|
-91.64%
|
|
3/1/2011
|
Hicks Karen A
|
VP Human Resources
|
775
|
$8.51
|
165.60%
|
|
3/1/2011
|
Hicks Karen A
|
VP Human Resources
|
-1,243
|
$30.00
|
-100.00%
|
|
3/1/2011
|
Brennan Jeffrey P
|
SVP - Bus. & Commercial Dev.
|
-1,264
|
$30.00
|
-100.00%
|
|
3/1/2011
|
Caldwell William S
|
SVP - Drug Discovery and Dev.
|
-11,360
|
$30.00
|
-59.49%
|
|
2/28/2011
|
Caldwell William S
|
SVP - Drug Discovery and Dev.
|
-15,481
|
$28.00
|
-66.68%
|
|
2/28/2011
|
Caldwell William S
|
SVP - Drug Discovery and Dev.
|
15,481
|
$5.55
|
200.14%
|
|
2/16/2011
|
Caldwell William S
|
SVP - Drug Discovery and Dev.
|
16,655
|
$1.75
|
215.32%
|
|
2/16/2011
|
Caldwell William S
|
SVP - Drug Discovery and Dev.
|
-16,655
|
$26.52
|
-68.29%
|
|
1/19/2011
|
Bencherif Merouane
|
SVP, Preclinical Research
|
-30,203
|
$27.09
|
-100.00%
|
|
1/19/2011
|
Bencherif Merouane
|
SVP, Preclinical Research
|
22,252
|
$1.75
|
279.86%
|
|
1/19/2011
|
Richard John P
|
Director
|
-5,000
|
$27.11
|
-48.39%
|
|
1/19/2011
|
Richard John P
|
Director
|
5,000
|
$2.71
|
93.76%
|
|
1/18/2011
|
Bencherif Merouane
|
SVP, Preclinical Research
|
-22,800
|
$27.17
|
-100.00%
|
|
1/18/2011
|
Richard John P
|
Director
|
-2,500
|
$27.38
|
-31.92%
|
|
1/18/2011
|
Richard John P
|
Director
|
2,500
|
$2.71
|
46.88%
|
|
1/14/2011
|
Hicks Karen A
|
VP Human Resources
|
-1,719
|
$27.50
|
-100.00%
|
|
1/13/2011
|
Hicks Karen A
|
VP Human Resources
|
-3,369
|
$27.24
|
-100.00%
|
|
1/12/2011
|
Hicks Karen A
|
VP Human Resources
|
-11,231
|
$27.18
|
-100.00%
|
|
1/12/2011
|
Hicks Karen A
|
VP Human Resources
|
5,225
|
$2.93
|
87.00%
|
|
1/11/2011
|
Hicks Karen A
|
VP Human Resources
|
3,294
|
$8.51
|
31.28%
|
|
1/11/2011
|
Hicks Karen A
|
VP Human Resources
|
-13,825
|
$27.02
|
-100.00%
|