|
Date |
Name |
Title |
Volume |
Trade Price |
Holding Change |
|
2/20/2013
|
BROOKE PAUL A
|
Director
|
10,000
|
$1.77
|
9.57%
|
|
2/6/2013
|
BROOKE PAUL A
|
Director
|
10,000
|
$1.77
|
9.57%
|
|
12/27/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
10,000
|
$1.84
|
49.59%
|
|
12/24/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
-17,500
|
$22.53
|
-31.72%
|
|
12/24/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
17,500
|
$1.84
|
46.46%
|
|
12/24/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
-17,500
|
$22.53
|
-46.46%
|
|
12/13/2012
|
BROOKE PAUL A
|
Director
|
-60,000
|
$23.87
|
-36.47%
|
|
12/10/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
-14,999
|
$24.07
|
-28.48%
|
|
12/10/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
14,999
|
$9.96
|
39.82%
|
|
12/10/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
-50,000
|
$24.07
|
-57.03%
|
|
12/10/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
50,000
|
$8.86
|
132.74%
|
|
12/10/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
10,000
|
$5.91
|
26.55%
|
|
12/10/2012
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
-10,000
|
$24.07
|
-20.98%
|
|
12/3/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
-10,000
|
$24.80
|
-18.35%
|
|
12/3/2012
|
DOUGHERTY MICHAEL R
|
Director
|
2,500
|
$25.07
|
55.56%
|
|
12/3/2012
|
Wolf John Peter III
|
VP, General Counsel
|
-18,000
|
$24.85
|
-100.00%
|
|
11/30/2012
|
GLASER ROBERT
|
Director
|
10,000
|
$20.15
|
24.18%
|
|
11/30/2012
|
GLASER ROBERT
|
Director
|
-20,000
|
$24.78
|
-32.59%
|
|
11/30/2012
|
GLASER ROBERT
|
Director
|
-10,000
|
$24.78
|
-19.47%
|
|
11/30/2012
|
GLASER ROBERT
|
Director
|
20,000
|
$3.00
|
48.36%
|
|
11/28/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
-2,500
|
$24.22
|
-4.39%
|
|
11/28/2012
|
MILANO VINCENT
|
President and CEO
|
18,000
|
$3.55
|
19.06%
|
|
11/28/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
-15,000
|
$24.22
|
-21.58%
|
|
11/28/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
15,000
|
$10.76
|
27.52%
|
|
11/28/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
2,500
|
$5.68
|
4.59%
|
|
11/13/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
12,500
|
$5.68
|
22.94%
|
|
11/13/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
-12,500
|
$25.01
|
-18.66%
|
|
11/13/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
-10,000
|
$24.84
|
-15.50%
|
|
11/13/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
10,000
|
$9.15
|
18.35%
|
|
11/8/2012
|
MILANO VINCENT
|
President and CEO
|
42,000
|
$5.91
|
44.48%
|
|
11/8/2012
|
MILANO VINCENT
|
President and CEO
|
-42,000
|
$24.54
|
-30.79%
|
|
11/8/2012
|
MILANO VINCENT
|
President and CEO
|
41,418
|
$3.14
|
43.87%
|
|
11/8/2012
|
MILANO VINCENT
|
President and CEO
|
-41,418
|
$24.54
|
-30.49%
|
|
11/2/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
-10,000
|
$25.37
|
-15.50%
|
|
6/11/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
-10,000
|
$20.04
|
-13.42%
|
|
6/11/2012
|
CLAYPOOL WILLIAM D MD
|
Director
|
10,000
|
$3.42
|
15.50%
|
|
3/23/2012
|
Pietrusko Robert
|
VP, Regulatory & Quality
|
-20,000
|
$30.00
|
-82.91%
|
|
3/23/2012
|
Pietrusko Robert
|
VP, Regulatory & Quality
|
20,000
|
$8.86
|
485.20%
|
|
3/9/2012
|
Fletcher Robert C.
|
V.P., Business Development
|
2,000
|
$3.93
|
873.36%
|
|
3/9/2012
|
Fletcher Robert C.
|
V.P., Business Development
|
5,000
|
$2.09
|
224.32%
|
|
3/9/2012
|
Fletcher Robert C.
|
V.P., Business Development
|
25,000
|
$3.55
|
345.83%
|
|
3/9/2012
|
Fletcher Robert C.
|
V.P., Business Development
|
-32,000
|
$29.66
|
-99.29%
|
|
3/9/2012
|
Morris Richard Steven
|
Chief Accounting Officer
|
1,300
|
$7.05
|
104.50%
|
|
3/9/2012
|
Morris Richard Steven
|
Chief Accounting Officer
|
-1,300
|
$29.71
|
-51.10%
|
|
3/9/2012
|
SOLAND DANIEL B
|
VP, Chief Operating Officer
|
6,561
|
$15.24
|
15.30%
|
|
3/9/2012
|
SOLAND DANIEL B
|
VP, Chief Operating Officer
|
5,001
|
$9.96
|
10.11%
|
|
3/9/2012
|
SOLAND DANIEL B
|
VP, Chief Operating Officer
|
5,555
|
$13.50
|
10.20%
|
|
3/9/2012
|
SOLAND DANIEL B
|
VP, Chief Operating Officer
|
31,176
|
$12.83
|
51.96%
|
|
3/9/2012
|
SOLAND DANIEL B
|
VP, Chief Operating Officer
|
-21,071
|
$29.65
|
-23.11%
|
|
3/7/2012
|
Rowland Charles A Jr
|
VP, Chief Financial Officer
|
25,083
|
$11.96
|
146.47%
|
|
3/7/2012
|
Rowland Charles A Jr
|
VP, Chief Financial Officer
|
5,555
|
$13.50
|
13.16%
|
|
3/7/2012
|
Rowland Charles A Jr
|
VP, Chief Financial Officer
|
-12,715
|
$29.49
|
-26.62%
|
|
3/5/2012
|
Morris Richard Steven
|
Chief Accounting Officer
|
3,300
|
$7.05
|
265.27%
|
|
3/5/2012
|
Morris Richard Steven
|
Chief Accounting Officer
|
2,000
|
$5.91
|
44.01%
|
|
3/5/2012
|
Morris Richard Steven
|
Chief Accounting Officer
|
-5,300
|
$33.01
|
-80.99%
|
|
3/5/2012
|
DOYLE THOMAS F
|
VP Strategic Initiatives
|
20,000
|
$3.93
|
38.14%
|
|
3/5/2012
|
DOYLE THOMAS F
|
VP Strategic Initiatives
|
30,000
|
$2.09
|
41.41%
|
|
3/5/2012
|
DOYLE THOMAS F
|
VP Strategic Initiatives
|
100,000
|
$3.55
|
97.61%
|
|
3/5/2012
|
DOYLE THOMAS F
|
VP Strategic Initiatives
|
60,000
|
$3.14
|
29.64%
|
|
3/5/2012
|
DOYLE THOMAS F
|
VP Strategic Initiatives
|
-210,000
|
$32.48
|
-80.02%
|
|
3/1/2012
|
Rowland Charles A Jr
|
VP, Chief Financial Officer
|
35,000
|
$11.96
|
117.15%
|
|
3/1/2012
|
Rowland Charles A Jr
|
VP, Chief Financial Officer
|
10,000
|
$5.91
|
15.41%
|
|
3/1/2012
|
Rowland Charles A Jr
|
VP, Chief Financial Officer
|
25,000
|
$8.86
|
33.39%
|
|
3/1/2012
|
Rowland Charles A Jr
|
VP, Chief Financial Officer
|
-70,000
|
$32.12
|
-70.09%
|
|
3/1/2012
|
Rowland Charles A Jr
|
VP, Chief Financial Officer
|
-12,750
|
$32.11
|
-42.68%
|
|
3/1/2012
|
SOLAND DANIEL B
|
VP, Chief Operating Officer
|
-30,000
|
$32.99
|
-41.16%
|
|
1/4/2012
|
MILANO VINCENT
|
President and CEO
|
-7,224
|
$27.91
|
-7.11%
|
|
1/4/2012
|
MILANO VINCENT
|
President and CEO
|
7,205
|
$27.91
|
7.63%
|
|
1/4/2012
|
MILANO VINCENT
|
President and CEO
|
2,795
|
$27.91
|
3.05%
|
|
12/29/2011
|
Fletcher Robert C.
|
V.P., Business Development
|
-1,071
|
$27.93
|
-82.38%
|
|
12/29/2011
|
Fletcher Robert C.
|
V.P., Business Development
|
-1,131
|
$27.93
|
-87.00%
|
|
12/23/2011
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
17,500
|
$1.84
|
90.03%
|
|
12/14/2011
|
Baker Biotech Capital (GP), LLC
|
TenPercent
|
50,566
|
$27.29
|
2.64%
|
|
12/14/2011
|
Baker Brothers Life Sciences Capital (GP), LLC
|
TenPercent
|
291,706
|
$27.29
|
3.05%
|
|
12/14/2011
|
14159 capital (GP), LLC
|
TenPercent
|
7,828
|
$27.29
|
2.65%
|
|
12/14/2011
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
-25,000
|
$25.17
|
-56.26%
|
|
12/14/2011
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
-25,000
|
$25.50
|
-56.26%
|
|
12/14/2011
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
25,000
|
$8.71
|
128.61%
|
|
12/13/2011
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
22,330
|
$7.05
|
114.87%
|
|
12/13/2011
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
-22,330
|
$23.50
|
-53.46%
|
|
12/12/2011
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
-17,670
|
$23.50
|
-47.62%
|
|
12/12/2011
|
Broom Colin MD
|
VP & Chief Scientific Officer
|
17,670
|
$7.05
|
90.90%
|
|
12/5/2011
|
MILANO VINCENT
|
President and CEO
|
15,000
|
$2.09
|
19.68%
|
|
12/5/2011
|
MILANO VINCENT
|
President and CEO
|
4
|
$3.93
|
0.01%
|
|
12/1/2011
|
DOYLE THOMAS F
|
VP Strategic Initiatives
|
-10,000
|
$23.82
|
-16.01%
|
|
12/1/2011
|
DOYLE THOMAS F
|
VP Strategic Initiatives
|
10,000
|
$20.16
|
19.07%
|
|
11/30/2011
|
Pietrusko Robert
|
VP, Regulatory & Quality
|
20,000
|
$9.99
|
511.51%
|
|
11/30/2011
|
Pietrusko Robert
|
VP, Regulatory & Quality
|
-20,000
|
$24.00
|
-83.65%
|
|
11/28/2011
|
Pietrusko Robert
|
VP, Regulatory & Quality
|
-19,000
|
$23.00
|
-82.93%
|
|
11/28/2011
|
Pietrusko Robert
|
VP, Regulatory & Quality
|
19,000
|
$9.99
|
485.93%
|
|
11/28/2011
|
GLASER ROBERT
|
Director
|
-5,000
|
$23.00
|
-11.94%
|
|
11/28/2011
|
GLASER ROBERT
|
Director
|
5,000
|
$3.00
|
13.56%
|
|
11/23/2011
|
Pietrusko Robert
|
VP, Regulatory & Quality
|
-1,000
|
$23.00
|
-25.58%
|
|
11/23/2011
|
Pietrusko Robert
|
VP, Regulatory & Quality
|
1,000
|
$9.99
|
34.36%
|
|
11/21/2011
|
MILANO VINCENT
|
President and CEO
|
15,000
|
$2.09
|
19.68%
|
|
11/21/2011
|
MILANO VINCENT
|
President and CEO
|
-15,000
|
$22.53
|
-16.45%
|
|
11/21/2011
|
MILANO VINCENT
|
President and CEO
|
19,996
|
$3.93
|
26.24%
|
|
11/21/2011
|
MILANO VINCENT
|
President and CEO
|
-19,996
|
$22.53
|
-20.78%
|
|
11/21/2011
|
MILANO VINCENT
|
President and CEO
|
41,691
|
$3.55
|
54.71%
|
|
11/21/2011
|
MILANO VINCENT
|
President and CEO
|
-41,691
|
$22.53
|
-35.36%
|